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Discovery of new genes associated with heart attacks

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An international consortium of scientists reports the discovery of five new genes that affect the risk of developing coronary artery disease (CAD) and heart attacks in a study published in the open-access journal PLoS Genetics.

Coronary artery disease is the most common cause of premature death and disability in the world and has a strong but incompletely characterised genetic contribution. The identification of the roles of various genes in the onset of heart disease could help in the development of new treatments and improve prediction of CAD. The study also demonstrated that some associations between genes and CAD, suggested by other, smaller studies, are spurious, according to Dr Adam Butterworth, who co-ordinated the analysis.

The consortium examined 49,094 genetic variants in ~2,100 genes of cardiovascular relevance in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent, and 4,394 cases and 4,259 controls of South Asian origin) and replicated their principal findings in an additional 17,121 CAD cases and 40,473 controls.

Ref and Read more: http://www.health.am/vein/more/genes-affecting-the-risk-of-coronary-artery-disease/

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